Journal
CELL METABOLISM
Volume 25, Issue 3, Pages 506-521Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2017.02.006
Keywords
-
Categories
Funding
- Gilead Sciences International Research Scholars Program in Liver Disease
- Abisch Frenkel Foundation for the Promotion of Life Sciences
- Gurwin Family Fund for Scientific Research
- Leona M. and Harry B. Helmsley Charitable Trust
- Crown Endowment Fund for Immunological Research
- estate of J. Gitlitz
- estate of L. Hershkovich
- Benoziyo Endowment Fund for the Advancement of Science
- Adelis Foundation
- French National Center for Scientific Research (CNRS)
- V.R. Schwartz Research Fellow Chair
- European Research Council
- Marie Curie Integration grant
- German-Israeli Foundation for Scientific Research and Development
- Israel Science Foundation
- Minerva Foundation
- Rising Tide Foundation
- Helmholtz Foundation
- European Foundation for the Study of Diabetes
Ask authors/readers for more resources
In addition to the immune system's traditional roles of conferring anti-infectious and anti-neoplastic protection, it has been recently implicated in the regulation of systemic metabolic homeostasis. This cross-talk between the immune and the metabolic systems is pivotal in promoting metabolic health throughout the life of an organism and plays fundamental roles in its adaptation to ever-changing environmental makeups and nutritional availability. Perturbations in this intricate immune-metabolic cross-talk contribute to the tendency to develop altered metabolic states that may culminate in metabolic disorders such as malnutrition, obesity, type 2 diabetes mellitus (T2DM), and other features of the metabolic syndrome. Regulators of immune-metabolic interactions include host genetics, nutritional status, and the intestinal microbiome. In this Perspective, we highlight current understanding of immune-metabolism interactions, illustrate differences among individuals and between populations in this respect, and point toward future avenues of research possibly enabling immune harnessing as means of personalized treatment for common metabolic disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available