Journal
BIOTECHNOLOGY JOURNAL
Volume 12, Issue 6, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201700052
Keywords
Bacterial microcompartments; Chloroplast; Mitochondrion; Pathway compartmentalization; Peroxisome
Funding
- Virginia Tech [175323]
- Junior Faculty Award of Institute for Critical Technology and Applied Science from Virginia Tech [J0663185]
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Sub-cellular compartments create specialized reaction chambers in eukaryotes. These compartments provide favorable micro-environments for many metabolic processes. Recently, metabolic engineers have explored the concept of pathway compartmentalization to enhance the performance of metabolic pathways. This strategy offers many unique advantages, including (i) increased local concentrations of enzymes and substrates, (ii) accessing alternate substrate pools, (iii) separation from competing reactions, and (iv) isolation of harmful intermediates or conditions needed for the pathway. In this review, the method of localizing metabolic pathways into specific organelles as well as the benefits of pathway compartmentalization in terms of enhancing the production of value-added chemicals is discussed.
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