Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 12, Pages 3172-3176Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201611118
Keywords
alkynes; C-H activation; manganese; peptides; reaction mechanisms
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Funding
- European Research Council under the European Community's Seventh Framework Program (FP7 )/ERC [307535]
- CSC
- CaSuS
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Manganese(I)-catalyzed C-H alkynylations with organic halides occurred with unparalleled substrate scope, and thus enabled step-economical C-H functionalizations with silyl, aryl, alkenyl, and alkyl haloalkynes. The versatility of the manganese(I) catalysis manifold enabled C-H couplings with haloalkynes featuring, among others, fluorescent labels, steroids, and amino acids, thereby setting the stage for peptide ligation as well as the efficient molecular assembly of acyclic and cyclic peptides. A plausible catalytic cycle was proposed.
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