Journal
CANCER CELL
Volume 31, Issue 3, Pages 326-341Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2017.02.009
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Funding
- Ludwig Institute for Cancer Research, University of Lausanne
- Swiss League for Cancer Research
- US National Cancer Institute [R01CA181355]
- Breast Cancer Research Foundation
- Cancer Research UK Grand Challenge
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The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the immune-suppressive environment. We also highlight recent advances in therapeutically targeting the brain TME in cancer. By developing a comprehensive understanding of the complex and interconnected microenvironmental landscape of brain malignancies we will greatly expand the range of therapeutic strategies available to target these deadly diseases.
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