Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/4698167
Keywords
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Funding
- State Key Projects on Infection Diseases of China [2012ZX10002017-005, 2012ZX10002016-023, 2012ZX10002010-001-007]
- National Natural Science Foundation of China [81372243, 81370575, 81301331]
- Guangdong Natural Science Foundation [2014A030313131, 2015A030313756, 2015A030312013, 2016A030313195]
- Science and Technology Planning Project of Guangdong Province [2014B020228003, 2014B030301041, 2015B020226004]
- Science and Technology Planning Project of Guangzhou [201400000001-3, 158100076, 2013J4100081]
- Guangzhou Municipal Health Bureau [20141A011117, 20151A011112]
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Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. Its role in the hepatocellular carcinoma (HCC) prognosis has not been investigated. In this study, we investigated whether TXNRD1 functions as an independent prognostic factor for HCC patients. We found TXNRD1 was overexpressed in HCC tissues and cells, immunohistochemical analysis suggested TXNRD1 was elevated in 57 of 120 (47.5%) clinical samples, and its level was increased with the increasing clinical stage. In addition, TXNRD1 expression was positively correlated with clinical stage (p = 3.5e - 5), N classification (p = 4.4e - 4), and M classification (p = 0.037) of HCC patients. Kaplan-Meier analysis revealed that patients with high TXNRD1 expression had significantly shorter survival time than patients with low TXNRD1 expression. Multivariate analysis found TXNRD1 was an independent prognostic factor for HCC patients. In conclusion, our data suggested that TXNRD1 was a biomarker for the prognosis of patients with HCC.
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