Journal
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
Volume 71, Issue -, Pages 57-68Publisher
POLISH ACAD SCIENCES, INST IMMUNOL & EXP THERAPY
DOI: 10.5604/17322693.1229823
Keywords
oxidative stress; NADPH oxidase; atherosclerosis
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Reactive oxygen species (ROS) play a key role in the pathogenesis of atherosclerosis. The main mechanisms which are involved are low-density lipoprotein oxidative modification, inactivation of nitric oxide and modulation of redox-sensitive signaling pathways. ROS contribute to several aspects of atherosclerosis including endothelial cell dysfunction, monocyte/macrophage recruitment and activation, stimulation of inflammation, and inducing smooth muscle cell migration and proliferation. NADPH oxidase is the main source of ROS in the vasculature. This enzyme consists of a membrane-bound heterodimer of gp91(phox) and p22(phox), cytosolic regulatory subunits p47(phox), p67(phox) and p40(phox), and small GTP-binding proteins rac1 and rac 2. Seven distinct isoforms of this enzyme have been identified, of which four (NOX1, 2, 4 and 5) may have cardiovascular function. In this paper, we review the current state of knowledge concerning the role of oxidative stress and NOX enzymes in pathogenesis of atherosclerosis. Moreover, we analyze the experimental studies that explore the relationship between the NOX family and atherosclerosis.
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