Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 10, Pages 8480-8489Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b14800
Keywords
dendritic cells; cell tracking; tannic acid; functionalized gold core-shell nanoparticles; detection limit; PET imaging
Funding
- National Research Foundation of Korea (NRF) grant - Korean government (MSIP) [2009-0078222, 2009-0078234]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI16C1501]
- National Nuclear R&D Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2012M2A2A7014020]
- Medical Cluster R&D Support Project through the Daegu-Gyengbuk Medical Innovation Foundation (DGMIF) - Ministry of Health Welfare [HT13C0002]
- BK21 PlusKNU Biomedical Convergence Program
- Department of Biomedical Science, Kyungpook National University
- National Research Foundation of Korea (NRF) Grant - Korea Government (MSIP) [2014R1A1A1003323, NRF-2015M2A2A7A01045177]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health Welfare [HI15C0001]
- Medical Cluster R&D support project through the Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) - Ministry of Health & Welfare, Republic of Korea [HT15c0003]
- Radiation Technology R&D program through the National Research Foundation of Korea - Ministry of Science, ICT & Future Planning [NRF-2012M2A2A7013480]
- Korea Health Promotion Institute [HR15C0009010017, HI16C1501070017] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2015M2A2A7A01045177, 2014R1A1A1003323] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
The development of highly sensitive, stable, and biocompatible imaging agents allowing visualization of dendritic cell (DC) migration is one of the essential factors for effective DC-based immunotherapy. Here, we used a novel and efficient synthesis approach to develop radioiodine-124-labeled tannic acid gold core shell nanoparticles(I-124-TA-Au@AuNPs) for DC labeling and in vivo tracking of their migration using positron emission tomography (PET). I-124-TA-Au@AuNPs were produced within 40 min in high yield via straightforward tannic acid-mediated radiolabeling chemistry and incorporation of Au shell, which resulted in high radio-sensitivity and excellent chemical stability of nanoparticles in DCs and living mice. I-124-TA-Au@AuNPs demonstrated good DC labeling efficiency and did not affect cell biological functions, including proliferation and phenotype marker expression. Importantly, I-124-TA-Au@AuNPs in an extremely low amount (0.1 mg/kg) were successfully applied to track the migration of DCs to lymphoid organs (draining lymph nodes) in mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available