Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 516, Issue -, Pages 238-244Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2016.12.029
Keywords
Solvent displacement; Polycaprolactone; Nanoparticles; Size; Zeta potential; Formulation optimization
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Funding
- French ministry of foreign affairs and Afghanistan higher education ministry
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Solvent displacement in comparison with other polymeric particles preparation technique provides certain crucial advantages such as water, time and energy lower consumption, procedure and set-up simplicity in nanoparticles preparation. The objective of this study was optimization of formulation in terms of the particle size, size distribution, zeta potential and morphology. In this study polycaprolactone based nanoparticles were prepared by solvent displacement or nanoprecipitation method. To prepare nanoparticles firstly, polycaprolactone was dissolved in acetone that form organic phase, secondly, for aqueous phase preparation, Tween 80 and polyvinyl alcohol as stabilizer of the system, were dissolved in the water. Consecutively, under magnetic agitation organic phase was injected through a syringe to the aqueous phase. Acetone was removed under reduced pressure by rotavapor. Furthermore, different formulation and process related variables such as evaporation technique, organic phase injection method and rate, stabilizer nature, polymer concentration, Tween 80 and polyvinyl alcohol concentration, stirring speed, organic and aqueous phases volume, were studied. To conclude, systematic study is indispensable before investigation of any drug encapsulation. (C) 2016 Elsevier B.V. All rights reserved.
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