Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 97, Issue -, Pages 417-426Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2015.08.004
Keywords
Chitosan; Chitosan derivatives; Carboxymethyl chitosan; Trimethyl chitosan; Biopolymers; Wound healing; Wound dressings; Skin regeneration; Drug delivery; Polyelectrolytes
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Funding
- Sciex-NMS [12.191]
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Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethyl-chitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,N-trimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described. (C) 2015 Elsevier BM. All rights reserved.
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