Journal
BIOSENSORS & BIOELECTRONICS
Volume 89, Issue -, Pages 689-692Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2015.11.052
Keywords
Graphene; Redesigned GPCR; Ionic screening; Field effect transistor
Categories
Funding
- Defense Advanced Research Projects Agency (DARPA)
- U.S. Army Research Office [W911NF1010093]
- National Science Foundation Accelerating Innovation in Research program [AIR ENG1312202]
- Nano/Bio Interface Center NSF [NSEC DMR0832802]
- FAER (Foundation for Anesthesia Education and Research)
- NIH K08 [K08-GM-093115-01]
- NIH R01 [1RO1GM111421-01]
- GROFF
- Department of Anesthesiology and Critical Care at the University of Pennsylvania
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Liquid-based applications of biomolecule-decorated field-effect transistors (FETs) range from biosensors to in vivo implants. A critical scientific challenge is to develop a quantitative understanding of the gating effect of charged biomolecules in ionic solution and how this influences the readout of the FETs. To address this issue, we fabricated protein-decorated graphene FETs and measured their electrical properties, specifically the shift in Dirac voltage, in solutions of varying ionic strength. We found excellent quantitative agreement with a model that accounts for both the graphene polarization charge and ionic screening of ions adsorbed on the graphene as well as charged amino acids associated with the immobilized protein. The technique and analysis presented here directly couple the charging status of bound biomolecules to readout of liquid-phase FETs fabricated with graphene or other two-dimensional materials. (C) 2015 Elsevier B.V. All rights reserved.
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