Journal
BIOMARKERS IN MEDICINE
Volume 11, Issue 2, Pages 179-194Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2016-0287
Keywords
biomarkers; blood and tissue; breath; culture; diagnostics; metabolites; metabolomics; sputum; tuberculosis; urine
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Funding
- National Research Foundation of South Africa [95269, 94217]
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Numerous studies have contributed to our current understanding of the complex biology of pulmonary tuberculosis and subsequently provided solutions to its control or eradication. Metabolomics, a newcomer to the Omics research domain, has significantly contributed to this understanding by identifying biomarkers originating from the disease- associated metabolome adaptations of both the microbe and host. These biomarkers have shed light on previously unknown disease mechanisms, many of which have been implemented toward the development of improved diagnostic strategies. In this review, we will discuss the role that metabolomics has played in tuberculosis research to date, with a specific focus on new biomarker identification, and how these have contributed to improved disease characterization and diagnostics, and their potential clinical applications.
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