Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 96, Issue -, Pages 143-151Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2015.07.016
Keywords
Dry powder inhaler; Extrafine aerosol; ICS; Lung deposition; Small airway targeting; Submicron particles
Categories
Funding
- AstraZeneca
Ask authors/readers for more resources
There is increasing interest in the use of so-called 'extrafine' aerosols to target the small airways in the management of asthma and COPD. Using previously presented deposition data, we assessed whether submicron (<1 mu m) particles can improve central and deep lung deposition. Our data show instead that particles in the range 1-3 mu m are much more relevant in this respect. Based on this finding the Symbicort Turbuhaler, Seretide Diskus, Rolenium Elpenhaler and Foster (Fostair) NEXThaler ICS/LABA combination DPIs were tested in vitro as a function of the pressure drop (2,4 and 6 kPa) across the inhaler. Obtained fine particle fractions (FPFs) <5 mu m (as percent of label claim) were divided into subfractions <1,1-3 and 3-5 mu m. Differences of up to a factor of 4 were found between the best (Turbuhaler) and worst performing DPI (Elpenhaler), particularly for the FPF in the size range 1-3 mu m. The NEXThaler, described as delivering 'extrafine' particles, did not appear to be superior in this size range. The marked differences in amount and size distribution of the aerosols between the devices in this study must cause significant differences in the total lung dose and drug distribution over the airways. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available