Journal
DEVELOPMENTAL NEUROBIOLOGY
Volume 77, Issue 2, Pages 158-168Publisher
WILEY
DOI: 10.1002/dneu.22450
Keywords
oxytocin; oxytocin receptor; perinatal; adolescence; aging
Categories
Funding
- Chica and Heinz Schaller Research Foundation
- German Research Foundation (DFG) [GR 3619/4-1]
- Human Frontier Science Program [RGP0019/2015]
- DFG within the Collaborative Research Center (SFB) [1134, 1158]
- Fritz Thyssen Research Foundation [10.16.2.018MN]
- CNR Research Project on Aging and Regione Lombardia (Project MbMM-convenzione) [18099/RCC]
- Accademia dei Lincei (Rome, Italy
- G. Levi post-doctoral fellowship)
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The hypothalamic neuropeptide oxytocin (OT) is a forefront molecule among neuropeptides due to its pronounced prosocial effects and its potential use in socioemotional deficits that characterize the most prevalent neurodevelopmental and psychiatric disorders (autism spectrum disorders and schizophrenia). The effects of OT have been studied in young and adult subjects (either animals or humans), while the complete lifespan trajectories of OT system development and activity have been far less investigated. In this (mini) review, we will primarily focus on three temporal distinct periods of lifeearly postnatal period, puberty/adolescence, and elderly. We selected the neonatal period to discuss the role of OT in the switch of GABA action from excitation to inhibition in the first days after birth (in rodents), with potential implications in neurodevelopmental disorders. In the puberty/adolescence period, we consider of particular relevance the OT impact on drug consumption, stress and aggression. Finally, OT could potentially contribute to maintain social capacities of aged people and to ameliorate socially emotional deficits and symptoms of neurodegenerative diseases. (c) 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 158-168, 2017
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