Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 96, Issue -, Pages 264-271Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2015.08.007
Keywords
Medical device; Controlled release; Hollow steel implant; Orthopedic surgery; Antibiotic; Staphylococcus aureus
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Funding
- Coordenacao de Aperfeicoamento de Nivel Superior (CAPES) from the Brazilian government [0927/12]
- ERC Consolidator Grant program [ERC-2013-CoG-614715]
- VI National RDi Plan
- Instituto de Salud Carlos III
- European Regional Development Fund
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A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
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