Journal
WIENER MEDIZINISCHE WOCHENSCHRIFT
Volume 167, Issue 1-2, Pages 2-8Publisher
SPRINGER WIEN
DOI: 10.1007/s10354-016-0496-4
Keywords
Pagetic bone; Bone structure; Histology; Histomorphometry; Skeletal disorder
Categories
Funding
- postdoctoral fellowship-University of Granada, Spain
- Medical University of Vienna
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Paget's disease of bone (PDB) is a noninflammatory, metabolic, skeletal disorder characterized by localized excessive osteoclastic bone resorption that is followed by compensatory increased osteoblastic activity leading to unstructured, fibroblastic, and biomechanically unstable bone. As a result, there is deformity and enlargement of the bone with a defective and disorganized pattern. Here, we review the epidemiology, etiology, pathology, macrostructure, histology, and quantitative histomorphometry findings of PDB. Hyperosteoclastosis and poor definition of the boundary between cortical and medullary bone are the main histological findings in PDB. Additionally, Pagetic bone is also characterized by hypertrophy and alteration of trabecular parameters.
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