Domino Reaction of ortho-Carbonylated Alkyne-Substituted Arylaldehydes with Arylsulfinic Acids: Efficient Access to Sulfonyl-Functionalized Indanones

An acid-mediated domino reaction of ortho-carbonylated alkynyl arylaldehydes with arylsulfinic acids provides rapid access to a variety of sulfonyl-functionalized indanones in high yields. The proposed reaction mechanism involves a domino process that comprises the hydrolysis of an ynone motif, a Knoevenagel condensation reaction, and a thia-Michael addition reaction. Thus, a one-step operation enables the formation of C-C and C-S bonds. This transformation benefits from simple reaction conditions, readily available starting materials, and good substrate scope.