Journal
CHEMICAL REVIEWS
Volume 117, Issue 6, Pages 4669-4713Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.6b00690
Keywords
-
Categories
Funding
- National Institutes of Health
- NIH [GM33775, GM31756, GM110428, GM118145]
- NIGMS MIRA award
Ask authors/readers for more resources
Membrane proteins play a most important part in metabolism, signaling, cell motility, transport, development, and many other biochemical and biophysical processes which constitute fundamentals of life on the molecular level. Detailed understanding of these processes is necessary for the progress of life sciences and biomedical applications. Nanodiscs provide a new and powerful tool for a broad spectrum of biochemical and biophysical studies of membrane proteins and are commonly acknowledged as an optimal membrane mimetic system that provides control over size, composition, and specific functional modifications on the nanometer scale. In this review we attempted to combine a comprehensive list of various applications of nanodisc technology with systematic analysis of the most attractive features of this system and advantages provided by nanodiscs for structural and mechanistic studies of membrane proteins.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available