Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 135, Issue 4, Pages 351-357Publisher
WILEY
DOI: 10.1111/acps.12701
Keywords
suicide; depression; old-age
Categories
Funding
- Swedish Research Council [11267, 2005-8460, 825-2007-7462, 825-2012-5041, 2013-2699, 2013-8717, 2015-02830, 2016-01590]
- Swedish Research Council for Health, Working Life and Welfare [2001-2646, 2001-2835, 2003-0234, 2004-0150, 2006-0020, 2008-1229, 2004-0145, 2006-0596, 2008-1111, 2010-0870, 2012-1138, 2016-07097, AGECAP 2013-2300, Epilife 2006-1506]
- Swedish Brain Power
- Knut and Alice Wallenberg Foundation
- Alzheimer's Association Zenith Award [ZEN-01-3151]
- Alzheimer's Association [IIRG-00-2159]
- Bank of Sweden Tercentenary Foundation
- Eivind och Elsa K:son Sylvans stiftelse
- Stiftelsen Soderstrom-Konigska Sjukhemmet
- Konung Gustaf V:s och Drottning Victorias Frimurarstiftelsen
- Stiftelsen for Gamla Tjanarinnor
- Handlanden Hjalmar Svenssons Forskningsfond
- Demensforbundet
- Stiftelsen Langmanska kulturfonden
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Objective: To investigate possible relationships between suicidal ideation and cerebrospinal fluid (CSF) levels of glial markers YKL-40 (also known as chitinase-3-like protein 1), growth-associated protein-43 (GAP-43) and myelin basic protein (MBP). Method: The sample was obtained from the Prospective Population Study of Women and included 86 women without dementia who underwent both psychiatric examinations and lumbar puncture (LP). Eight of these women reported past-month suicidal ideation. Results: Significantly, higher CSF levels of both YKL-40 and GAP-43 were detected in women with past-month suicidal ideation. Associations with suicidal ideation remained for both YKL-40 and GAP-43 in regression models adjusted for smoking status, BMI and age. CSF levels of YKL-40, GAP-43 and MBP did not differ by depression status. Higher levels of CSF GAP-43 were associated with feelings of worthlessness; a strong relationship was demonstrated in the fully adjusted model (OR 5.95 CI [1.52-23.20], P = 0.01). Conclusion: Our findings of elevated CSF concentrations of both YKL40 and GAP-43 in women with suicidal ideation, compared to those without, suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults.
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