Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 46, Issue 8, Pages 2002-2012Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2017.1408020
Keywords
Nanotechnology; drug delivery systems; nanostructures; cardiotoxicity; cancer
Categories
Funding
- Fundacao de Apoio a Pesquisa do Distrito Federal (FAP/DF) [0193.001020/2015]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [447628/2014-3]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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Nanocapsules (NCS-DOX) with an oily core of selol and a shell of poly(methyl vinyl ether-co-maleic anhydride) covalently conjugated to doxorubicin were developed. These nanocapsules are spherical, with an average hydrodynamic diameter of about 170nm, and with negative zeta potential. NCS-DOX effectively co-delivered the selol and the doxorubicin into 4T1 cells and changed the intracellular distribution of DOX from the nuclei to the mitochondria. Moreover, a significantly increased cytotoxicity against 4T1 cells was observed, which is suggestive of additive or synergic effect of selol and doxorubicin. In conclusion, PVM/MA nanocapsules are suitable platforms to co-deliver drugs into cancer cells.
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