Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 45, Issue 8, Pages 1751-1761Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2017.1282868
Keywords
Zinc oxide nanoparticles; green synthesis; Ziziphus nummularia; antifungal activity; cytotoxic activity
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Funding
- UGC-CAS, New Delhi
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Zinc oxide nanoparticles (ZnO NPs) were synthesized using Ziziphus nummularia leaf extract. The characterization was done by various spectral analysis and antifungal (anti-candidal) activity against multidrug resistant clinical isolates and their cytotoxic potential was evaluated. The ZnO NPs were 17.33nm in size and were spherical/irregular in shape. The antifungal activity of ZnO NPs was better than four standard azole antibiotics and they also showed potent cytotoxic effect against HeLa cancer cell line. The results strongly suggest the applicability of green synthesized ZnO NPs as antifungal agent and also its use in cancer diagnosis and treatment.
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