Journal
CHEMOSPHERE
Volume 171, Issue -, Pages 595-600Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2016.12.127
Keywords
Polycystic ovary syndrome; Organochlorine pesticides; Endocrine disrupting; Serum
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Funding
- Program for Xiamen Southern Oceanographic Center [14GST69NF33]
- project of the Xiamen Science and Technology Program [2013Z20134027]
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To investigate the serum concentrations of organochlorine pesticides (OCPs) in patients with polycystic ovary syndrome (PCOS), a total of 178 women were studied. The concentrations of hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT) in serum were determined using Gas Chromatography Mass-Mass Spectrometer. No differences with statistical significance in the mean HCH, p,p'-DDD, p,p'-DDE concentrations were observed between the patients with PCOS and the control group. Serum p,p'-DDT (P = 0.016) and o,p'-DDT (P = 0.000) levels were significantly higher in patients with PCOS compared with the control group. The results of the association between OCPs levels and hormone levels indicated that o,p'-DDT may play a role in the pathogenesis of PCOS by affecting hormones levels. Further trials should be investigated with the findings in this study to obtain new pathogenesis of PCOS. (C) 2016 Elsevier Ltd. All rights reserved.
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