Journal
CELL
Volume 169, Issue 1, Pages 13-23Publisher
CELL PRESS
DOI: 10.1016/j.cell.2017.02.007
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Funding
- NIH [HG002668, P01-CA042063]
- Austrian Science Fund FWF [J3490]
- Margaret and Herman Sokol Postdoctoral Award
- National Cancer Institute [P30-CA14051]
- Austrian Science Fund (FWF) [J3490] Funding Source: Austrian Science Fund (FWF)
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Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals.
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