Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 24, Pages 3438-3441Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc10275a
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Funding
- National Natural Science Foundation of China [21472056, 21602070]
- Fundamental Research Funds for the Central Universities [CCNU15ZX002, CCNU16A05002]
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An I-2-promoted formal [3+2] cycloaddition for access to oxazoles has been demonstrated. This is the first example of a Lewis acid-promoted formal [3+2] cycloaddition of isocyanides with methyl ketones involving the C equivalent to N cleavage of isocyanides. The salient feature of this approach is unconventional 2,5-disubstituted oxazole formation from isocyanides and ketones rather than 4,5-substituted oxazoline.
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