Journal
DEVELOPMENTAL CELL
Volume 40, Issue 4, Pages 354-366Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2017.01.010
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Funding
- Uehara Memorial Foundation
- JSPS
- IST Austria
- Cancer Research UK [FC001317]
- UK Medical Research Council [FC001317]
- Wellcome Trust [FC001317]
- Austrian Science Fund (FWF) [I3196] Funding Source: Austrian Science Fund (FWF)
- Cancer Research UK [21144] Funding Source: researchfish
- The Francis Crick Institute [10317] Funding Source: researchfish
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Embryo morphogenesis relies on highly coordinated movements of different tissues. However, remarkably little is known about how tissues coordinate their movements to shape the embryo. In zebrafish embryogenesis, coordinated tissue movements first become apparent during doming, when the blastoderm begins to spread over the yolk sac, a process involving coordinated epithelial surface cell layer expansion and mesenchymal deep cell intercalations. Here, we find that active surface cell expansion represents the key process coordinating tissue movements during doming. By using a combination of theory and experiments, we show that epithelial surface cells not only trigger blastoderm expansion by reducing tissue surface tension, but also drive blastoderm thinning by inducing tissue contraction through radial deep cell intercalations. Thus, coordinated tissue expansion and thinning during doming relies on surface cells simultaneously controlling tissue surface tension and radial tissue contraction.
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