Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 10, Pages 1607-1610Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc08826k
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Funding
- National Research Council of Science & Technology (NST) grant - Republic of Korea [CRC-15-04-KIST]
- Ministry of Health & Welfare, Republic of Korea [HI14C3344]
- National Medical Research Council [NMRC/CBRG/1438/2015]
- Brain Research Program through the National Research Foundation of Korea (NRF) [2016M3C7A1913844]
- National Research Council of Science & Technology (NST), Republic of Korea [CRC-15-04-KIST] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.
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