Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 85, Issue -, Pages 79-86Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2016.11.118
Keywords
Cigarette smoke; Alzheimer's disease; Ischemic stroke; Oxidative stress; Neurodegeneration
Funding
- MidCareer Researcher Program through the National Research Foundation of Korea [NRF-2015R1A2A2A09001059]
- Department of Science and Technology
- New Delhi [VI/D&P/349/10-11/TDT/1]
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Cigarette smoking is known to be harmful to health, and is considered the main cause of death worldwide, especially in India. Among the well-distinguished diseases related to smoking are, chronic obstructive pulmonary disease, oral and peripheral cancers, and cardiovascular complications. However, the impact of cigarette smoking on neurocognitive and neuropathological effects, including anxiety, Alzheimer's disease, Parkinson's disease, ischemic stroke, and blood-brain barrier dysfunction, still remains unclear. Cigarette smoke consists of more than 4500 toxic chemicals that combine to form free radicals, which lead to oxidative stress-associated neurological disorders. Herein, we discuss the role of antioxidant agents in delaying or attenuating disease complications. In addition, in this review, we discuss the neuropathological effect of cigarette smoke and its interference in neurodegeneration. (C) 2016 Elsevier Masson SAS. All rights reserved.
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