Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 88, Issue -, Pages 1090-1097Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2017.01.151
Keywords
Ozone oxidative preconditioning; Ischemia-reperfusion injury; Heart; Mitochondrial injury
Funding
- National Natural Science Foundation of China [81170230]
- Development Program for Key National Clinical Department
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Ischemia-reperfusion injury (IRI) is a major cause of cardiac dysfunction during cardiovascular surgery, heart transplantation and cardiopulmonary bypass procedures. The purpose of the present study was to explore, firstly, whether ozone induces oxidative preconditioning by activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and, secondly, whether ozone oxidative preconditioning (OzoneOP) can protect the heart against IRI by attenuating mitochondrial damage. Rats were subjected to 30 min of cardiac ischemia followed by 2 h of reperfusion, with or without prior OzoneOP (100 mu g/kg/day) for 5 days. Antioxidant capacity, myocardial apoptosis and mitochondrial damage were evaluated and compared at the end of reperfusion. OzoneOP was found to increase antioxidant capacity and to protect the myocardium against IRI by attenuating mitochondrial damage and myocardial apoptosis. The study suggests a potential role for OzoneOP in protecting the heart against IRI during cardiovascular surgery, cardiopulmonary bypass procedures or transplantation. (C) 2017 Elsevier Masson SAS. All rights reserved.
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