Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 5, Issue 6, Pages 4837-4845Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.7b00273
Keywords
Gluten; Gold quantum cluster; Luminescence; Creatinine; Biosensor
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Funding
- Indian Institute of Space Science and Technology (IIST)
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Protein mediated syntheses of fluorescent noble metal quantum clusters have proven to be particularly attractive owing to their high stability and biocompatibility. Here, we present the cost-effective synthesis of novel, water-soluble, and stable fluorescent gold quantum clusters via a facile and green method using wheat gluten protein as a stabilizing agent (Au-QC@gluten). Gluten, a cysteine-rich protein serves as an effective stabilizing agent for these clusters. The Au-QC@gluten shows intense red emission at similar to 680 nm and is characterized using UV-vis spectroscopy, fluorescence, Fourier-transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). Contrary to any other protein protected gold quantum cluster, Au-QC@gluten is highly stable toward reactive oxygen species like H2O2, revealing its promising application in biomedical fields such as bioimaging, biolabeling, etc. The red emitting Auqc@gluten has been applied in the detection of creatinine with high sensitivity and selectivity. The detection limit is found to be 2 nM in the linear range from 20 mu M to 520 mu M. This method allows the accurate detection of creatinine in clinical blood samples, indicating its promising biomedical applications.
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