Journal
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Volume 5, Issue 11, Pages 9542-9553Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.7b01707
Keywords
Deep eutectic solvents; Cryopreservation; Vitrification; Cryoprotective agents; Glycerol
Categories
Funding
- FCT through the project Des.zyme - Biocatalytic separation of enantiomers using Natural Deep Eutectic Solvents [PTDC/BBB-EBB/1676/2014]
- European Union Seventh Framework Programme (FP7) [REGPOT-CT2012-316331-POLARIS]
- European Regional Development Fund (ERDF) under the project Novel smart and biomimetic materials for innovative regenerative medicine approaches [RL1-ABMR-NORTE-01-0124-FEDER-000016]
- North Portugal Regional Operational Programme (ON.2, O Novo Norte), under the National Strategic Reference Framework (NSRF)
- Fundação para a Ciência e a Tecnologia [PTDC/BBB-EBB/1676/2014] Funding Source: FCT
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Recent findings have reported the reason why some living beings are able to withstand the huge thermal amplitudes between winter and summer in their natural habitats. They are able to produce metabolites decreasing deeply the crystallization temperature of water, avoiding cell disrupture due to the presence of ice crystals and overcoming osmotic effects. In vitro, the possibility to cool living cells and tissues to cryogenic temperatures in the absence of ice can be achieved through a vitrification process. Vitrification has been suggested as an alternative approach to cryopreservation and could hereafter follow an interesting biomimetic perspective. The metabolites produced by these animals are mostly sugars, organic acids, choline derivatives, or urea. When combined at a particular composition, these compounds form a new liquid phase which has been defined as Natural Deep Eutectic Solvents (NADES). In this review, we relate the findings of different areas of knowledge from evolutive biology, cryobiology, and thermodynamics and give a perspective to the potential of NADES in the development of new cryoprotective agents.
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