Journal
JOURNAL OF BIOMIMETICS BIOMATERIALS AND BIOMEDICAL ENGINEERING
Volume 30, Issue -, Pages 76-85Publisher
TRANS TECH-SCITEC PUBLICATIONS LTD
DOI: 10.4028/www.scientific.net/JBBBE.30.76
Keywords
biofilm; bacterial cellulose; mangosteen peel extract; breast cancer
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In Indonesia, breast cancer is noted as the most common cancer in women. Accordingly, this research was conducted to synthesize biofilm from bacterial cellulose by adding ethanol extract of mangosteen peel. The pellicle of bacterial cellulose was soaked in a 100 mL ethanol solution of mangosteen peel extract varied by 0.5%, 1%, 1.5%, and 2% v/v. The samples were characterized using the SEM, FTIR, and MTT Assay using the T47D breast cancer cells. The results using the SEM showed the thickness of the bacterial cellulose biofilm samples was 5.63 mum, while the 2% v/v thickness of the bacterial cellulose of the extract of mangosteen peel biofilm samples was 12.2 mum. The FTIR results showed a weak interaction between the O-H groups of the microbial cellulose and the C=C functional group in the phenolic compounds of the mangosteen peel extract. Based on the MTT Assay test results using the T47D breast cancer cells, the highest percentage of cell death result was 25.47% on the 2% v/v bacterial cellulose of the mangosteen peel extract samples. The Garcinia mangostana extracts added in the bacterial cellulose biofilms still required optimal concentrations in order to become potential killing mechanism for the T47D breast cancer cells.
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