Journal
CATALYSIS LETTERS
Volume 147, Issue 3, Pages 633-639Publisher
SPRINGER
DOI: 10.1007/s10562-016-1964-6
Keywords
Bis-Michael reaction; Glucoamylase; Enzyme catalysis; Quaternary carbon center
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Funding
- National Natural Science Foundation of China [21472152, 21672174]
- Basic and Frontier Research Project of Chongqing [cstc2015jcyjBX0106]
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Bio-catalytic bis-Michael reaction for the construction of quaternary carbon centers is reported. Glucoamylase from Aspergillus niger (AnGA) was used as a sustainable and eco-friendly catalyst. Various highly substituted trans-cyclohexanones with a quaternary carbon center were obtained with yields of up to 92%. As a novel case of enzyme promiscuity, this work provides a bio-catalytic alternative for construction of quaternary carbon centers. Glucoamylase from Aspergillus niger (AnGA) catalyzed the bis-Michael addition of (1E,4E)-1,5-diarylpenta-1,4-dien-3-ones with active methylene compounds to form various highly substituted trans-cyclohexanones with a quaternary carbon center.
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