Journal
TOXINS
Volume 9, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/toxins9100307
Keywords
disintegrin; blood vessel formation; VEGF; antioxidant enzymes; oxidative stress biomarkers
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Funding
- Sao Paulo State Research Foundation (FAPESP) [2012/10993-4, 2013/00798-2]
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Alternagin-C (ALT-C) is a disintegrin-like protein isolated from Rhinocerophis alternatus snake venom, which induces endothelial cell proliferation and angiogenesis. The aim of this study was to evaluate the systemic effects of a single dose of alternagin-C (0.5 mgkg-1, via intra-arterial) on oxidative stress biomarkers, histological alterations, vascular endothelial growth factor (VEGF) production, and the degree of vascularization in the liver of the freshwater fish traira, Hoplias malabaricus, seven days after the initiation of therapy. ALT-C treatment increased VEGF levels and hepatic angiogenesis. ALT-C also enhanced hepatic antioxidant enzymes activities such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, decreasing the basal oxidative damage to lipids and proteins in the fish liver. These results indicate that ALT-C improved hepatic tissue and may play a crucial role in tissue regeneration mechanisms.
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