Journal
CIRCULATION RESEARCH
Volume 120, Issue 7, Pages 1174-1182Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.117.303776
Keywords
caveolin-1; endothelial cells; heart failure; nitrates; nitric oxide
Funding
- National Institutes of Health [R01 HL64793, R01 HL61371, R01 HL081190, P01 HL1070295]
- American Heart Association (Innovative Research Grant Merit Award)
- German Research Foundation (DFG) [KR 4268/1-1]
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Endothelial cells lining the vessel wall control important aspects of vascular homeostasis. In particular, the production of endothelium-derived nitric oxide and activation of soluble guanylate cyclase promotes endothelial quiescence and governs vasomotor function and proportional remodeling of blood vessels. Here, we discuss novel approaches to improve endothelial nitric oxide generation and preserve its bioavailability. We also discuss therapeutic opportunities aimed at activation of soluble guanylate cyclase for multiple cardiovascular indications.
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