Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 6, Issue 5, Pages 1316-1320Publisher
WILEY
DOI: 10.1002/sctm.16-0360
Keywords
Angiogenesis; Cellular therapy; Endothelial cell; Progenitor cells
Categories
Funding
- Juvenile Diabetes Research Foundation
- Fight for Sight
- Leverhulme Trust
- National Eye Research Centre
- Australian National Health and Medical Research Council (NHMRC)
- National Institutes of Health Grant [DK106846]
- Riley Children's Foundation
- Sir Jules Thorn Trust
- Invest Northern Ireland
- MRC [MC_PC_16083, G0600053, G0801962] Funding Source: UKRI
- Fight for Sight [1871/72, 1891/92, 1315/16, 1883/84] Funding Source: researchfish
- Medical Research Council [MC_PC_16083, G0801962, G0600053] Funding Source: researchfish
- The Sir Jules Thorn Charitable Trust [10JTA] Funding Source: researchfish
Ask authors/readers for more resources
Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general lack of concordance in the stem cell field with many distinct cell subtypes continually grouped under the term EPC. It would be highly advantageous to agree on standards to confirm an endothelial progenitor phenotype and this should include detailed immunophenotyping, potency assays, and clear separation from hematopoietic angiogenic cells which are not endothelial progenitors. In this review, we seek to discourage the indiscriminate use of EPCs, and instead propose precise terminology based on defining cellular phenotype and function. Endothelial colony forming cells and myeloid angiogenic cells are examples of two distinct and well-defined cell types that have been considered EPCs because they both promote vascular repair, albeit by completely different mechanisms of action. It is acknowledged that scientific nomenclature should be a dynamic process driven by technological and conceptual advances; ergo the ongoing EPC nomenclature ought not to be permanent and should become more precise in the light of strong scientific evidence. This is especially important as these cells become recognized for their role in vascular repair in health and disease and, in some cases, progress toward use in cell therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available