Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 6, Issue 11, Pages 2044-2052Publisher
WILEY
DOI: 10.1002/sctm.17-0081
Keywords
Stem/progenitor cell; Stem cell transplantation; Nervous system; Neural differentiation; Mesenchymal stem cells
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Funding
- Medical Faculties of the University of Duisburg-Essen (IFORES)
- University of Goettingen
- Volkswagen Foundation
- Stem Cell Network North Rhine Westphalia
- LeitmarktAgentur.NRW
- European Union (European Regional Development Fund)
- European Union [BM1202]
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Despite recent advances in stroke therapy, current therapeutic concepts are still limited. Thus, additional therapeutic strategies are in order. In this sense, the transplantation of stem cells has appeared to be an attractive adjuvant tool to help boost the endogenous regenerative capacities of the brain. Although transplantation of stem cells is known to induce beneficial outcome in (preclinical) stroke research, grafted cells do not replace lost tissue directly. Rather, these transplanted cells like neural progenitor cells or mesenchymal stem cells act in an indirect manner, among which the secretion of extracellular vesicles (EVs) appears to be one key factor. Indeed, the application of EVs in preclinical stroke studies suggests a therapeutic role, which appears to be noninferior in comparison to the transplantation of stem cells themselves. In this short review, we highlight some of the recent advances in the field of EVs as a therapeutic means to counter stroke.
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