Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 7, Issue 2, Pages 155-160Publisher
OXFORD UNIV PRESS
DOI: 10.1002/sctm.17-0223
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [SFB 655]
- Sachsisches Staatsministerium fur Wissenschaft und Kunst [4-7531.60/29/31]
- DFG [SFB655]
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The cell surface antigen prominin-1 (alias CD133) has gained enormous interest in the past 2 decades and given rise to debates as to its utility as a biological stem and cancer stem cell marker. Important and yet often overlooked knowledge that is pertinent to its physiological function has been generated in other systems given its more general expression beyond primitive cells. This article briefly discusses the importance of particular biochemical features of CD133 with relation to its association with membrane microdomains (lipid rafts) and proper immunodetection. It also draws attention toward the adequate use of detergents and caveats that may apply to the interpretation of the results generated.
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