Journal
CANCER INVESTIGATION
Volume 35, Issue 2, Pages 129-141Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2016.1272695
Keywords
Head and neck cancer; sphingosine-1-phosphate; sphingosine kinase 2; lipid phosphate phosphatase; miR-95-3p
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Funding
- Science and Engineering Research Board (SERB), Govt. of India's Scheme for Young Scientist research grant [SB/YS/LS-184/2013]
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We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes (SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of SphK1 and SGPP1 genes was up-regulated significantly in 70% and 75% OSCC tumors respectively. Importantly, expression of SphK2 and PPAP2B was down-regulated in the tumor tissues of 70% OSCC patients. Expression of SphK2 and PPAP2B negatively correlated with tumor-node-metastasis (TNM) staging and tumor volume respectively. Furthermore, LPP1 is an independent predictor of TNM staging and lymph node ratio.
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