Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 11, Pages 1884-1887Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc09994g
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Funding
- American Cancer Society [RSG-13-102-01-CCE]
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Photo-unclick chemistry mediates visible and near IR-controlled drug release via a singlet oxygen (SO)-cleavable linker. Due to the limited diffusion distance of SO in biological systems, a photosensitizer and the SO-cleavable linker have been conjugated in one molecule or mixed in nano-drug delivery systems. In this communication, we demonstrate a new strategy to activate prodrugs with photo-unclick chemistry in an intermolecular fashion using an SO-cleavable CA4 prodrug and a mitochondria-specific photosensitizer, protoporphyrin IX, formed from prodrug hexyl-5-aminolevulinate.
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