Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 13, Pages 2174-2177Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc09882g
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- NIAID NIH HHS [R01 AI097119] Funding Source: Medline
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JIB-04, a specific inhibitor of the O-2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O-2 in KDM4A/JMJD2A through a continuous O-2-consumption assay, X-ray crystal structure data, and molecular docking.
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