Journal
BRITISH JOURNAL OF NUTRITION
Volume 117, Issue 1, Pages 21-29Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114516004591
Keywords
Muscle strength; Muscle fatigue resistance; Muscle force production; Myogenesis; Protein synthesis
Categories
Funding
- JSPS KAKENHI grant [26560371, 16K12942, 16K16450, 16K13022, 26350818, 15K01711]
- JSPS Fellows [14J00286]
- Ministry of Agriculture, Forestry and Fisheries
- Integration Research for Agriculture and Interdisciplinary Fields (Bio-oriented Technology Research Advancement Institution, NARO) [14532022]
- Council for Science, Technology and Innovation
- SIP (NARO) [14533567]
- Nakatomi Foundation
- All Japan Coffee Association
- Vascular Disease Research Foundation
- Naito Foundation
- Descente Sports Foundation
- Graduate School of Health Sciences, Toyohashi Sozo University
- Grants-in-Aid for Scientific Research [16K16450, 16K13022, 14J00286, 26350818, 16K12942, 26560371, 15K01711] Funding Source: KAKEN
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Diets enriched with advanced glycation end products (AGE) have recently been related to muscle dysfunction processes. However, it remains unclear whether long-term exposure to an AGE-enriched diet impacts physiological characteristics of skeletal muscles. Therefore, we explored the differences in skeletal muscle mass, contractile function and molecular responses between mice receiving a diet high in AGE (H-AGE) and low in AGE (L-AGE) for 16 weeks. There were no significant differences between L-AGE and H-AGE mice with regard to body weight, food intake or epididymal fat pad weight. However, extensor digitorum longus (EDL) and plantaris (PLA) muscle weights in H-AGE mice were lower compared with L-AGE mice. Higher levels of N-e-(carboxymethyl)-L-lysine, a marker for AGE, in EDL muscles of H-AGE mice were observed compared with L-AGE mice. H-AGE mice showed lower muscle strength and endurance in vivo and lower muscle force production of PLA muscle in vitro. mRNA expression levels of myogenic factors including myogenic factor 5 and myogenic differentiation in EDL muscle were lower in H-AGE mice compared with L-AGE mice. The phosphorylation status of 70-kDa ribosomal protein S6 kinase Thr(389), an indicator of protein synthesis signalling, was lower in EDL muscle of H-AGE mice than that of L-AGE mice. These findings suggest that long-term exposure to an AGE-enriched diet impairs skeletal muscle growth and muscle contractile function, and that these muscle dysfunctions may be attributed to the inhibition of myogenic potential and protein synthesis.
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