Journal
CYTOTHERAPY
Volume 19, Issue 4, Pages 445-457Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2017.02.002
Keywords
mesenchymal stem cell; gliomas; adenovirus; mesenchymal stromal cell
Categories
Funding
- National Cancer Institute [P50 CA127001]
- Broach Foundation for Brain Cancer Research
- Elias Family Fund
- Priscilla and Jason Hiley Fund
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Mesenchymal stromal cells (MSCs) are a type of adult stem cell that has been exploited for the treatment of a variety of diseases, including cancer. In particular, MSCs have been studied extensively for their ability to treat glioblastoma (GBM), the most common and deadly form of brain cancer in adults. MSCs are attractive therapeutics because they can be obtained relatively easily from patients, are capable of being expanded numerically in vitro, can be easily engineered and are inherently capable of homing to tumors, making them ideal vehicles for delivering biological antitumoral agents. Oncolytic viruses are promising biological therapeutic agents that have been used in the treatment of GBMs, and MSCs are currently being explored as a means of delivering these viruses. Here we review the role of MSCs in the treatment of GBMs, focusing on the intersection of MSCs and oncolytic viruses.
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