Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 113, Issue -, Pages 97-121Publisher
ELSEVIER
DOI: 10.1016/j.addr.2016.08.010
Keywords
Molecular imaging; Theranostics; Beacon; Smart probe; Fluorophore; Aggregation; Nanocarrier; Biosensing
Categories
Funding
- Terry Fox Research Institute (TFRI) [1022]
- Princess Margaret Cancer Foundation
- Canadian Institutes of Health Research [RMF111823, MOP119597, MOP133678]
- Ontario Institute for Cancer Research (ZHENG G-OICR-SIP)
- Natural Sciences and Engineering Research Council of Canada [NSERC-386613-10/UT#489078]
- Canada Foundation for Innovation [21765]
- Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research
- Knudson Postdoctoral Fellowship Program [KNUDSON FSHP 224]
Ask authors/readers for more resources
Molecular imaging has emerged as an indispensable technology in the development and application of drug delivery systems. Targeted imaging agents report the presence of biomolecules, including therapeutic targets and disease biomarkers, while the biological behaviour of labelled delivery systems can be non-invasively assessed in real time. As an imaging modality, fluorescence offers additional signal specificity and dynamic information due to the inherent responsivity of fluorescence agents to interactions with other optical species and with their environment. Harnessing this responsivity is the basis of activatable fluorescence imaging, where interactions between an engineered fluorescence agent and its biological target induce a fluorogenic response. Small molecule activatable agents are frequently derivatives of common fluorophores designed to chemically react with their target. Macromolecular scale agents are useful for imaging proteins and nucleic acids, although their biological delivery can be difficult. Nanoscale activatable agents combine the responsivity of fluorophores with the unique optical and physical properties of nanomaterials. The molecular imaging application and overall complexity of biological target dictate the most advantageous fluorescence agent size scale and activation strategy. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available