Journal
DATA IN BRIEF
Volume 11, Issue -, Pages 432-441Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dib.2017.02.046
Keywords
Alpha-tocopherol; Docosahexaenoic acid; Choline; Glucose; Ferroptosis
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Funding
- National Institutes of Health [S10RR027878]
- NIEHS [P30 E5000210]
- National Science Foundation [DGE 0965820]
- Helen P Rumbel endowment
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The data herein is in support of our research article by McDougall et al. (2017) [1], in which we used our zebrafish model of embryonic vitamin E (VitE) deficiency to study the consequences of VitE deficiency during development. Adult 5D wild-type zeb-rafish (Danio rerio), fed defined diets without (E-) or with VitE (E+, 500 mg RRR-alpha-tocopheryl acetate/kg diet), were spawned to obtain E- and E+ embryos that we evaluated using metabolomics and specific lipid analyses (each measure at 24, 48, 72, 120 hours post-fertilization, hpf), neurobehavioral development (locomotor responses at 96 hpf), and rescue strategies. Rescues were attempted using micro-injection into the yolksac using VitE (as a phospholipid emulsion containing d(6)-alpha-tocopherol at 0 hpf) or D-glucose (in saline at 24 hpf). (C) 2017 The Authors. Published by Elsevier Inc.
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