Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 162, Issue 6, Pages 746-749Publisher
SPRINGER
DOI: 10.1007/s10517-017-3703-4
Keywords
myocardium; metabolism; technetium-99m; fatty acid
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Using rat model of coronary occlusion, we studied pharmacokinetics and the efficiency of a new radiopharmaceutical agent Tc-99m-PDA-DTPA intended for diagnostics of changes in myocardial metabolism and its analogue I-123-PMPDA. Tc-99m-PDA-DTPA was eliminated mostly by the kidneys and maximal concentration in the heart was attained within 60 min after intravenous injection; no accumulation in the area of myocardial infarction was observed. The studied substance was inferior to its analogue 123I-PMPDA by the quality of scintigraphic visualization of the heart.
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