Journal
POLYMERS
Volume 9, Issue 8, Pages -Publisher
MDPI AG
DOI: 10.3390/polym9080318
Keywords
mechanical property; cell behavior; small diameter vascular graft; fibrin glue; rolling
Categories
Funding
- Ministry of Science and Technology of China [2013YQ190467]
- Chinese Academy of Sciences [XDA09030305]
- National Science Foundation of China [81361140345, 51373043, 21535001]
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In this paper, we investigate essential mechanical properties and cell behaviors of the scaffolds fabricated by rolling polylactic-co-glycolic acid (PLGA) electrospinning (ES) films for small-diameter vascular grafts (inner diameter < 6 mm). The newly developed strategy can be used to fabricate small diameter vascular grafts with or without pre-seeded cells, which are two main branches for small diameter vascular engineering. We demonstrate that the mechanical properties of our rolling-based scaffolds can be tuned flexibly by the number of layers. For cell-free scaffolds, with the increase of layer number, burst pressure and suture retention increase, elastic tensile modulus maintains unchanged statistically, but compliance and liquid leakage decrease. For cell-containing scaffolds, seeding cells will significantly decrease the liquid leakage, but there are no statistical differences for other mechanical properties; moreover, cells live and proliferate well in the scaffold after a 6-day culture.
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