Journal
NATURE REVIEWS IMMUNOLOGY
Volume 17, Issue 4, Pages 248-261Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2017.10
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Funding
- Deutsche Forschungsgemeinschaft [SO876/6-1, SO876/11-1, SFB914-B08, SFB1123-A01/A06/B05]
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (VIDI) [91712303]
- European Union (ITN Evolution) [692511]
- European Research Council [692511]
- Ministry of Economy, Industry and Competitiveness [SAF2015-65607-R]
- MINECO
- Pro CNIC Foundation
- Severo Ochoa Center of Excellence [SEV-2015-0505]
- European Research Council (ERC) [692511] Funding Source: European Research Council (ERC)
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Traditionally, neutrophils have been acknowledged to be the first immune cells that are recruited to an inflamed tissue and have mainly been considered in the context of acute inflammation. By contrast, their importance during chronic inflammation has been studied in less depth. This Review aims to summarize our current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues. We also scrutinize the roles of neutrophils in wound healing and the resolution of inflammation, and finally, we outline emerging therapeutic strategies that target neutrophils.
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