Journal
POLYMERS
Volume 9, Issue 10, Pages -Publisher
MDPI AG
DOI: 10.3390/polym9100469
Keywords
molecular imprinting; hypericin; click reaction; nanospheres
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Funding
- Project of Science and Technology of Social Development in Shaanxi Province [2016SF-029]
- National Natural Science Foundation of China [21174113, 21772157]
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To fabricate molecularly imprinted polymer nanospheres via click reaction, five different clickable compounds were synthesized and two types of click reactions (azide-alkyne and thiol-yne) were explored. It was found that molecularly imprinted polymer nanospheres could be successfully synthesized via thiol-yne click reaction using 3,5-diethynyl-pyridine (1) as the monomer, tris(3-mercaptopropionate) (tri-thiol, 5) as the crosslinker, and hypericin as the template (MIP-NSHs). The click polymerization completed in merely 4 h to produce the desired MIP-NSHs, which were characterized by FTIR, SEM, DLS, and BET, respectively. The reaction conditions for adsorption capacity and selectivity towards hypericin were optimized, and the MIP-NSHs synthesized under the optimized conditions showed a high adsorption capacity (Q = 6.03 molg-1) towards hypericin. The imprinting factors of MIP-NSHs towards hypericin, protohypericin, and emodin were 2.44, 2.88, and 2.10, respectively.
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