Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 112, Issue -, Pages 80-102Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2017.02.008
Keywords
Colorectal cancer; Murine animal model; Chemotherapy; Methodology; Core outcome dataset
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Funding
- Cancer Research UK [23924] Funding Source: researchfish
- National Institute for Health Research [ACF-2014-26-010, CL-2016-26-002] Funding Source: researchfish
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In vivo studies in animal models are critical tools necessary to study the fundamental complexity of carcinogenesis. A constant strive to improve animal models in cancer exists, especially those investigating the use of chemotherapeutic effectiveness. In the present systematic review, colorectal cancer (CRC) is used as an example to highlight and critically evaluate the range of reporting strategies used when investigating chemotherapeutic agents in the preclinical setting. A systematic review examining the methodology and reporting of preclinical chemotherapeutic drug studies using CRC murine models was conducted. A total of 45 studies were included in this systematic review. The literature was found to be highly heterogeneous with various cell lines, animal strains, animal ages and chemotherapeutic compounds/regimens tested, proving difficult to compare outcomes between similar studies or indeed gain any significant insight into which chemotherapeutic regimen caused adverse events. From this analysis we propose a minimum core outcome dataset that could be regarded as a standardised way of reporting results from in vivo experimentation. (C) 2017 Elsevier B.V. All rights reserved.
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