Journal
MATERIALS
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ma10040352
Keywords
haemocompatibility; nanodiamonds; spectroscopy; blood; biophotonics
Categories
Funding
- DS Programs of the Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology
- KNOW (Leading National Research Centre) Scientific Consortium Healthy Animal - Safe Food [05-1/KNOW2/2015]
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This study reports the interactions of modified nanodiamond particles in vitro with human blood. Modifications performed on the nanodiamond particles include oxygenation with a chemical method and hydrogenation upon chemical vapor deposition (CVD) plasma treatment. Such nanodiamonds were later incubated in whole human blood for different time intervals, ranging from 5 min to 5 h. The morphology of red blood cells was assessed along with spectral measurements and determination of haemolysis. The results showed that no more than 3% of cells were affected by the nanodiamonds. Specific modifications of the nanodiamonds give us the possibility to obtain nanoparticles which are biocompatible with human blood. They can form a basis for the development of nanoscale biomarkers and parts of sensing systems and devices useful in biomedical environments.
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