Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 152, Issue -, Pages 199-213Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2017.01.014
Keywords
Artificial cells; Cell mimicry; Encapsulated enzymatic reactions; Microreactors; Multi-compartment carriers
Funding
- Lundbeck Foundation, Denmark [R163-2013-15402]
- Lundbeck Foundation [R163-2013-15402] Funding Source: researchfish
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Compartmentalization is a key feature of biological cells which conduct their metabolic activity in individual steps isolated in distinct, separated compartments. The creation of architectures containing multiple compartments with a structure that resembles that of a biological cell has generated significant research attention and these assemblies are proposed as candidate materials for a range of biomedical applications. In this Review article, the recent successes of multicompartment architectures as carriers for the delivery of therapeutic cargo or the creation of micro- and nanoreactors that mimic metabolic activities, thus acting as artificial cells or organelles, are discussed. The developed technologies to assemble such complex architectures are outlined, the multicompartment carriers' properties which contribute to their performance in diverse applications are discussed, and their successful applications are highlighted. Finally, future directions and developments in the field are suggested. (C) 2017 Elsevier B.V. All rights reserved.
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